The study examined the effects of Institutional Infrastructure on production of graduates of five (5) South East Universities in Abia and Imo States. The specific objectives are the effect of the laboratories on student performance and the effect of lecture halls on student performance in South East universities. The study was conducted using a survey design methodology. The study adopts primary source of data where a well structured questionnaire was used to collect data. The data were analysed using Simple Regression analysis using SPSS version 21. Findings show that laboratories have a significant positive effect on student performance with a p-value (0.000) less than Alpha (0.05), while lecture halls have a significant positive effect on student performance. We, therefore, concluded that institutional infrastructure have significant positive effect on academic performance. We recommend that, higher institution managements should endeavour to improve on institutional infrastructure since it has significant positive effect on academic performance.