This study determined the impact of Knowledge Management on Organizational Competitiveness of Nigerian Breweries Enugu, Enugu State. Having analyzed the distributed 98 questionnaires, descriptive survey approach was adopted and analyzed using regressions with the help of SPSS version 22.0. The study found positive and significant effect of knowledge acquisition on competitive advantage of Nigerian Breweries Enugu, Enugu State. Secondly positive and significant effect of application of knowledge on competitive advantage of Nigerian Breweries Enugu, Enugu State. Therefore, knowledge is considered as an essential asset in any organization. Thus, many organizations are trying to apply Knowledge management in order to improve their organizational performance. This article has reviewed the positive impact of knowledge management and some of its practices on organizational competitive advantage. The study recommends the need for more knowledge acquisition in promoting awareness among senior managers and other employees in Nigerian Breweries Enugu. Knowledge acquisition is important for suppliers and customers because they are responsible for providing the latter group with resources that enable the organization to achieve excellence and a sustainable competitive advantage.